During her 2025 State of the Union, President Ursula von der Leyen announced the launch of a new EU Global Health Resilience Initiative (GHRI) — a major step towards strengthening global health systems, reinforcing health security, and building trust in science worldwide. We are proud to share that EUHA has contributed to the European Commission’s Call for Evidence on the GHRI. In our submission, EUHA underlined that university hospitals are essential infrastructure for health system resilience, and our alliance should be recognised as a strategic implementation partner of the Initiative. UNIVERSITY HOSPITALS AS KEY PLAYERS IN IMPLEMENTING THE EU GLOBAL HEALTH RESILIENCE INITIATIVE University hospitals are critical infrastructure for resilient health systems. University hospital networks such as EUHA connect specialised care, research, education, public health, and data systems at scale, across borders. They must be explicitly recognised as implementation partners, for translating policy into practice and delivering scalable solutions for health resilience. The GHRI should focus on a limited number of operational priorities where impact can be demonstrated: Sustainable Workforce Building resilient health systems starts with skilled and well-trained people. EUHA members are essential drivers of health workforce resilience by delivering specialised training programmes, joint curricula, and certification pathways. Through a long-term partnership, EUHA can help build sustainable capacity. Pandemic Preparedness University hospitals are pillars of pandemic preparedness and play a central role in surge capacity, complex case management, linking surveillance, laboratories, and frontline care. EUHA members are well prepared to contribute to global strategies and operationalise preparedness frameworks that bridge the gap between public health planning and frontline care delivery. Research, Innovation and Digital Health From clinical research to AI and data-driven healthcare, EUHA members can support the deployment of interoperable, well-governed, and equitable digital health solutions. Antimicrobial Resistance Antimicrobial resistance is a core pillar of health system resilience. University hospitals are critical actors in delivering antimicrobial stewardship, infection prevention and control, and surveillance—ensuring AMR is effectively tackled at the clinical frontline. Health Literacy and Disinformation University hospitals, as trusted sources of scientific and health information, are key partners in effective communication and in countering mis- and disinformation. EUHA calls on the European Commission to formally recognise university hospital networks as core GHRI actors and to establish frameworks for long‑term institutional partnerships. Tertiary and specialised care must be fully integrated into health system strengthening. EUHA stands ready to contribute to the design and implementation of the GHRI and to help ensure that the EU’s global health strategy is effective, operational and sustainable.